Even in absurdity, sacrament. Even in hardship, holiness. Even in doubt, faith. Even in chaos, realization. Even in paradox, blessedness
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"Life expands or shrinks in proportion to one's courage." ~Anain Nin
Drug Triggers Body's Mechanism To Reverse Aging Effect On Memory Process
A drug made to enhance memory appears to trigger a natural mechanism in the brain that fully reverses age-related memory loss, even after the drug itself has left the body, according to researchers at UC Irvine.
Professors Christine Gall and Gary Lynch, along with Associate Researcher Julie Lauterborn, were among a group of scientists who conducted studies on rats with a class of drugs known as ampakines. Ampakines were developed in the early 1990s by UC researchers, including Lynch, to treat age-related memory impairment and may be useful for treating a number of central nervous system disorders, such as Alzheimer’s disease and schizophrenia. In this study, the researchers showed that ampakine drugs continue to reverse the effects of aging on a brain mechanism thought to underlie learning and memory even after they are no longer in the body. They do so by boosting the production of a naturally occurring protein in the brain necessary for long-term memory formation.
The study appears in the August issue of the Journal of Neurophysiology.
“This is a significant discovery,” said Gall, professor of anatomy and neurobiology. “Our results indicate the exciting possibility that ampakines could be used to treat learning and memory loss associated with normal aging.”
The researchers treated two groups of middle-aged rats twice a day for four days with either a solution that contained ampakines or one that did not. They then studied the hippocampus region of the rats’ brains, an area critical for memory and learning. They found that in the ampakine-treated rats, there was a significant increase in the production of brain-derived neurotrophic factor (BDNF), a protein known to play a key role in memory formation. They also found an increase in long-term potentiation (LTP), the process by which the connection between the brain cells is enhanced and memory is encoded. This enhancement is responsible for long-term cognitive function, higher learning and the ability to reason. With age, deficits in LTP emerge, and learning and memory loss occurs.
Researchers, working with colleagues at St George’s, University of London, are developing drugs designed to stop allergens from entering the body, so rendering them harmless.
Professor David Garrod said the research – recently shortlisted for the Northwest Regional Development Agency’s Bionow Project of the Year – takes a completely new approach to the treatment and prevention of allergies.
“The technology is based on our earlier discovery of how allergens, the substances that cause allergy, enter the body through the surface layer of cells that protect the skin and the tubes of the lungs,” he said.
“Allergens from pollen or house dust mites are inhaled and then dissolve the binding material between the cells that form these protective linings; they can then enter the body by passing between the cells to cause an allergic response.
“The drugs we are developing – called Allergen Delivery Inhibitors (ADIs) – are designed to disable these allergens so they can no longer eat through the protective cell layer and block the allergic reaction before it occurs.
“The effect will be like avoiding allergens altogether. Removing carpets and rigorous cleaning of homes are established ways to avoid allergens, but they are only partially effective because their effects do not ‘travel’ with allergy sufferers.
Nanoparticles armed to combat cancer
Ultra-small particles loaded with medicine - and aimed with the precision of a rifle - are offering a promising new way to strike at cancer, according to researchers working at MIT and Brigham and Women's Hospital.
In a paper to appear the week of April 10 in the online edition of the Proceedings of the National Academy of Sciences, the team reports a way to custom design nanoparticles so they home in on dangerous cancer cells, then enter the cells to deliver lethal doses of chemotherapy. Normal, healthy cells remain unscathed.
The team conducted experiments first on cells growing in laboratory dishes, and then on mice bearing human prostate tumors. The tumors shrank dramatically, and all of the treated mice survived the study; the untreated control animals did not.
"A single injection of our nanoparticles completely eradicated the tumors in five of the seven treated animals, and the remaining animals also had significant tumor reduction, compared to the controls..."
Free and Clear? Caution over HIV 'cure' claims
Doctors say they want to investigate the case of a British man with HIV who apparently became clear of the virus. Andrew Stimpson, 25, was diagnosed HIV-positive in 2002 but was found to be negative in October 2003 by Chelsea and Westminster Healthcare NHS Trust. Mr Stimpson, from London, said he was "one of the luckiest people alive".
The trust said the tests were accurate but had been unable to confirm Scotsman Mr Stimpson's cure because he had declined to undergo further tests.
A statement from the trust said: "This is a rare and complex case. When we became aware of Mr Stimpson's HIV negative test results we offered him further tests to help us investigate and find an explanation for the different results.
Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature
Given the multifactorial nature of depression and anxiety, and the ambiguities inherent in psychiatric diagnosis and treatment, some have questioned whether the mass provision of SSRIs is the result of an over-medicalized society. These sentiments were voiced by Lord Warner, United Kingdom Health Minister, at a recent hearing: “I have some concerns that sometimes we do, as a society, wish to put labels on things which are just part and parcel of the human condition”. He went on to say, “Particularly in the area of depression we did ask the National Institute for Clinical Excellence [an independent health organisation that provides national guidance on treatment and prevention] to look into this particular area and their guideline on depression did advise non-pharmacological treatment for mild depression”. Sentiments such as Lord Warner's, about over-medicalization, are exactly what some pharmaceutical companies have sought to overcome with their advertising campaigns. For example, Pfizer's television advertisement for the antidepressant sertraline (Zoloft) stated that depression is a serious medical condition that may be due to a chemical imbalance, and that “Zoloft works to correct this imbalance”. Other SSRI advertising campaigns have also claimed that depression is linked with an imbalance of the neurotransmitter serotonin, and that SSRIs can correct this imbalance. The pertinent question is: are the claims made in SSRI advertising congruent with the scientific evidence?
Nanotech offers HIV cure?
I'mm too dense to get much of this, but it sounds good...
In the first-ever study of metal nanoparticles' interaction with HIV-1, silver nanoparticles of sizes 1-10nm attached to HIV-1 and prevented the virus from bonding to host cells...
Sweeping along 14th-century trade routes, an infectious agent left a trail of incomparable devastation throughout Asia and Europe. In China, this plague slashed the population from 125 million to 90 million by the century's end. In Cairo, the Black Death—so called because of the dark, swollen lymph nodes that characterize the disease—claimed 7,000 lives a day at its height. Before it subsided, the plague had wiped out one-third of Europe's population.
In most of the world today, the plague has receded to a distant, if gruesome, memory. So, too, at least in developed countries, have smallpox, typhoid fever, cholera, diphtheria, and polio declined. One by one, infectious diseases that once ravaged society and preyed especially on children have been quelled by better sanitation, antibiotics, and vaccinations.
While raising barricades against deadly scourges, however, the industrialized world has also shielded people from the microbes and parasites that do no harm. Does it matter?
Yum? You do what you eat
We already know obesity can result if we eat too much junk food, but there may be greater consequences of unhealthy diets than extra weight around our middles.... Is it simply coincidence that the increase in aggression, crime and social incivility in Western society has paralleled a spectacular change in our diet? Could there be a link between the two?
"Every day, a new medicine," he sighs. "It is so temporary, so changeable. We talk about anti-ageing, anti-this, anti-that. The anti word is so negative. Ageing is a natural process. Each phase of life should be equally celebrated. What we should be talking about is healthy ageing. A doctor should not be just for the sick patient but for healthy people."
Put like this, it is hard to disagree that as much may have been lost as gained by modern medical advance. Dubey finds that Western doctors are competent at looking after individual troublesome organs but puzzled by the concept of treating the whole person. Ayurvedic medicine (from ayus, meaning "life" and veda, meaning "science") is all-inclusive. In India, it is part of the national health service, offered in conjunction with conventional medicine in every hospital.
It sees the body as a little universe and each person as having a pattern of energy as unique and individual as a thumb print. The physiological energies that control the functions of the body are known as doshas. Each of us has three - fire (pitta), water (kapha) and air (vata) - and it is believed that an imbalance between the three causes disease. Getting the balance right enhances immunity, prevents illness and maintains health. "It's all about wellbeing," says Dubey, "about achieving a balance between ourselves and nature."
obsession with sickness
We live in a world where illnesses are on the increase. The distinguishing feature of the twenty-first century is that health has become a dominant issue, both in our personal lives and in public life. It has become a highly politicised issue, too, and an increasingly important site of government intervention and policymaking. With every year that passes, we seem to spend more and more time and resources thinking about health and sickness.... there is now a presupposition that illness is as normal as health. Earlier theories of medicalisation still considered illness to be the exception; now, being ill is seen as a normal state, possibly even more normal than being healthy. We are all now seen as being potentially ill; that is the default state we live in today.
ten famous names ignorant on a.i.d.s.
Dick Cheney and John Edwards: ...Moderator Gwen Ifill said she wanted to hear about AIDS -- "and not about AIDS in China or Africa," she made clear. "But AIDS right here in this country, where black women between the ages of 25 and 44 are 13 times more likely to die of the disease than their counterparts." At an obvious loss, Cheney mumbled about the global AIDS pandemic before admitting, "I had not heard those numbers, with respect to African-American women." The incidence of HIV infection among African-American women has far exceeded HIV cases among white women for at least a decade. How the vice president missed that is a mystery -- unless he never cared to know in the first place. Edwards fared no better, completely missing an opportunity to skewer the Bush administration for flat-funding the Ryan White CARE Act, ignoring prevention efforts for African-Americans and neglecting the AIDS Drug Assistance Program. Well, at least neither of them sputtered, "AIDS? I thought that was a gay disease!"
Hallucinogenic cure for alcoholism
Traditional curry ingredient helps fight Alzheimer's disease
The research team also determined curcumin is more effective in inhibiting formation of the protein fragments than many other drugs being tested as Alzheimer's treatments.
The latest on cure research: AIDS Treatment News ...the world's first treatment newsletter for people with HIV, reports on mainstream and alternative treatment, access to care, Web resources, public policy, and political action.
Meanwhile, a ban has been lifted on two generic antiretroviral treatments.
I am a Zambian lady aged 23 years old and am HIV Positive. I live in Lusaka, the capital city of Zambia and currently working as a volunteer in an organization which deals with the control of HIV/AIDS by way of giving care, support and Antiretroviral therapy to people infected with HIV. Having lost both parents at an early age, as well as a sister and two elder brothers due to HIV/AIDS. I have a great love for people and am more than ready to help HIV Positive persons like myself who are struggling to accept this great change in their lives and promote safe sex among young people so that the spread of HIV is put to an end.
My Mum works with children who live with HIV and she told me about it. She told me that some people can be horrible to people who have HIV and I get upset about that. I don't think you should be horrible to people who have HIV, they're just like everyone else.
Korean Scientists Succeed in Stem Cell Therapy (via FutureHi and MeFi)
A team of Korean researchers claimed Thursday they had performed a miracle by enabling a patient, who could not even stand up for the last 19 years, to walk with stem cell therapy. During a press conference, the scientists said they had last month transplanted multi-potent stem cells from umbilical cord blood to the 37-year-old female patient suffering from a spinal cord injury and she can now walk on her own.
The Asclepion is devoted to the study of ancient medicine. (via Plep)
That's probably all my posting for today, happy Saturday peeps.
Ancient remedy 'shrinks cancer' An
An ancient native American treatment for cancer has been shown to have a beneficial effect despite scepticism from the medical establishment. Chaparral, an evergreen desert shrub, has long been used by native Americans to treat cancer, colds, wounds, bronchitis, warts, and ringworm.
OK, so work didn't happen,
OK, so work didn't happen, so technically, this is a sick day. In honor of illness... it's Disease Trading Cards! Here's set two! There's diseases for everyone at the CDC 'kids' page!
in my place is a
in my place is a blog about living with HIV. Powerful stuff. [via MeFi]
Massachusetts prepares for gays to
Massachusetts prepares for gays to marry:
The government in Massachusetts this week showed the first clear signs of getting ready to issue marriage licenses for same-sex couples in May, but the threat of a possible court order to block the action still looms.
Study: Obesity an Epidemic in
Americans are sitting around and eating themselves to death, with obesity closing in on tobacco as the nation's No. 1 underlying preventable killer.
Mysterious virus may thwart HIV
Up to six years after their initial HIV-infection, men whose blood contained the second virus - known simply as GB virus C (GBV-C) - were nearly three times less likely to die than HIV-positive men who did not have the secondary infection.
'It's OK, I'm on the
Hundreds of healthy people in Africa, Cambodia and two U.S. cities will begin taking doses of a powerful AIDS drug as part of a series of studies into the use of medicine to stop HIV infection before it starts.
"A gastronomical guinea pig" Man
Man eats fast food for thirty days. Man falls apart. "He was an extremely healthy person who got very sick eating this Mc*******'s diet... None of us imagined he could deteriorate this badly - he looked terrible. The liver test was the most shocking thing - it became very, very abnormal."
What is The Meatrix?
What is The Meatrix?
World Aids Day sets HIV
Global health chiefs are to spell out plans to ensure three million people with HIV get the drugs they need by the end of 2005.
'Microbeam' makes cancer cells
A futuristic "microbeam" that zaps individual cancer cells with a stream of particles could revolutionise radiotherapy, scientists say.
Today is World AIDS Day
Today is World AIDS Day
Five people worldwide die of AIDS every minute of every day. HIV has hit every corner of the globe, infecting more than 42 million men, women and children, 5 million of them last year alone.
Stroke gives woman British accent
An American woman has been left with a British accent after having a stroke.
Guinness good for you The
The long-running ad campaign is well-known
Green tea extract may fight
Scientists in Japan have found a component of green tea can stop HIV from binding to healthy immune cells, which is how the virus spreads.
Scientists: Pill helps people unlearn
The drug, sold by Eli Lilly and Co. under the brand name Seromycin, doesn't dissolve fear. But in rats, it helped them unlearn fears faster, Davis said. Since it was already approved for use in people, he and Barbara O. Rothbaum, director of the school's trauma and anxiety recovery program, tested it on 28 acrophobics, people afraid of heights.
In pictures: Facing HIV Samkelisiwe
Samkelisiwe embraces her mother in the TB ward of Nquelezane Hospital, Natal, South Africa. Their picture is one of over 1000 taken by Positive Lives, a collaboration bringing together photographers, charities and people living with HIV.
Clinton brokers landmark Aids deal
Four companies that produce generic Aids drugs have agreed to reduce the cost of the drugs for millions of people in developing countries under a deal brokered by former US President Bill Clinton.
'My life with an
When people imagine an "iron lung", it is always in black and white.
Forbes, of all rags, asks
Forbes, of all rags, asks this
Fans of abstinence had better be sitting down. "Saving yourself" before the big game, the big business deal, the big hoedown or the big bakeoff may indeed confer some moral benefit. But corporeally it does absolutely zip. There's no evidence it sharpens your competitive edge. The best that modern science can say for sexual abstinence is that it's harmless when practiced in moderation. Having regular and enthusiastic sex, by contrast, confers a host of measurable physiological advantages, be you male or female.
Oh, great. Moralistic grandstanding versus
Oh, great. Moralistic grandstanding versus virulent epidemic... who will win?
The Catholic Church is telling people in countries stricken by Aids not to use condoms because they have tiny holes in them through which the HIV virus can pass - potentially exposing thousands of people to risk... The WHO has condemned the Vatican's views, saying: "These incorrect statements about condoms and HIV are dangerous when we are facing a global pandemic which has already killed more than 20 million people, and currently affects at least 42 million."
The same, but different... my
The same, but different... my job as it would be in the UK: Inner-city mentors 'tackling truancy' Counsellors brought in to deal with problems suffered by inner-city schools have been effective, an official report suggests.
Oy gevalt, today was stressful.
Oy gevalt, today was stressful. So, in order to straighten out my head and releive this tension headache, I'm going to go and laugh with friends. Which is a good thing, considering that yet another study has proven laughter to be healthy, indeed, prophylactic (insert pun here___________).
West's failure on Aids 'obscene'
West's failure on Aids 'obscene' The United Nations special envoy on HIV/Aids has denounced as a "grotesque obscenity" the lack of cheap anti-Aids drugs in Africa.
Herbal remedy secret uncovered British
Herbal remedy secret uncovered British scientists believe they may have discovered how the popular herbal remedy arnica works.
Western 'benefits' causing major health
Western 'benefits' causing major health problems in rest of world.
FightAIDS@Home FightAIDS@Home is the first
FightAIDS@Home FightAIDS@Home is the first biomedical distributed computing project ever launched. It is run by the Olson Laboratory at The Scripps Research Institute, and uses your computer to assist fundamental research to discover new drugs, using our growing knowledge of the structural biology of AIDS.
Mobiles 'make you senile' Mobile
Mobiles 'make you senile' Mobile phones and the new wireless technology could cause a "whole generation" of today's teenagers to go senile in the prime of their lives, new research suggests
Surprise? Written word helps wounds
Surprise? Written word helps wounds heal Pouring your emotions out on paper could help wounds heal quicker, researchers say.
Sage herb 'can boost memory'
Sage herb 'can boost memory' Centuries-old theories that the herb sage can improve memory appear to be borne out by modern research.
Justify my craving: Dark chocolate
Justify my craving: Dark chocolate may be good for you
Thai man dies while laughing
How's about some full strength
How's about some full strength irony: Sunscreen blamed for cancer
Visembryo is an interactive spiral
Visembryo is an interactive spiral map of fetal development, via MeFi
Recent adventures in medicine... Polar
Interview with Patch Adams "I
Interview with Patch Adams "I experimented with friendliness by calling hundreds of wrong numbers, pretending to be a sociology student, or anything that would help me draw people out. Out in public I engaged strangers in conversation as much as possible. For example I rode elevators to see how many floors it would take to get the occupants introduced to one another, and even singing songs."
Alrighty then: Wank for Health.
Alrighty then: Wank for Health. Suppose I'll be alright then... Frequent masturbation, particularly in the 20s, helps prevent prostate cancer later in life, according to new research. Australian scientists have shown that the more men masturbate between the ages of 20 and 50, the less likely they are to develop the disease that kills more than half a million men each year.
Bionic Eyes Benefit the Blind
Bionic Eyes Benefit the Blind More than just the stuff that $6 million men are made of, several types of "bionic eyes" are beginning to make their presence felt in the area where they are most needed -- restoring sight to the blind.
West Nile Spreading Rapidly
Rapid brain growth seen linked
Rapid brain growth seen linked to autism Infants whose heads suddenly begin to grow rapidly appear to be at risk of autism, perhaps indicating the increasingly common disorder may be traced to missed connections in fast-expanding brains, researchers said on Tuesday.
Manufacturing disease: New antibiotics 'could
Manufacturing disease: New antibiotics 'could prove deadly' "...other researchers say that it is quite possible that bacteria will acquire resistance - and when they do, this will make life far more difficult, as our own defence mechanisms will be rendered far less potent."
A Fatal Imbalance in Medical
A Fatal Imbalance in Medical Treatment "Doctors there were forced to treat late-stage sleeping sickness with an arsenic-based drug, melarsoprol, developed in 1949. Melarsoprol is excruciatingly painful to administer, kills one in 10 patients, and fails one in five. A more effective, less toxic drug, eflornithine, had been discovered several years earlier, but its production was halted because the manufacturer saw no profit in providing medicines to desperately poor people.
Sleeping sickness was neglected by the market, but by a remarkable stroke of luck a far more lucrative use for eflornithine was found - removing unwanted facial hair in women - and so it is back in production today. "
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Keep it even,
"Not all who wander
You contain everything
Everything contains you
If you desire the Infinite,
look no further than the window.
Ten Considerations for Being Well n this Goofy Universe
0. If you find yourself
wonderstruck, don’t forget to return the favor. 1. Always be of service to
the whole and the Holy. You’ll find that the Holy will reciprocate by being
of service to your becoming Whole. 2. You will be called upon
to use your mind and your vision in ways I cannot possibly glimpse. Never
turn down an offer to shine that light so uniquely yours to help others in
their darkness, and you’ll find that when it’s your turn to be in the night
that there’ll be someone along the way who happens to have a little glow to
share . 3. The rewards of being
true to yourself are infinite, even when outwardly your efforts are met
with nothing. 4. You’ll also see that
knowledge and wisdom will come from within yourself through your own
struggle and curiosity... your loved ones may guide you to insight, but
yours is the power to choose it. 5. You’ll find that some of
your choices could’ve been better, or at times were downright stupid. That’s
okay... I have a closet full of reckless decisions, but without making them
I wouldn’t have the slightest idea of what a good one might feel like if I
tried it on. 6. Your growth will be a
mysterious, comic, ecstatic and sometimes scary ride, and I pray that you
strive to savor each minute of it, even the most difficult or embarrassing
minutes. Don’t count on second chances. 7. In those times when
everything collapses around you, and what’s left won’t go right, don’t
forget your chances of being alive in this solar system, in this galaxy, are
a little on the slim side. So slim in fact that it could be called a miracle
to breathe this air, drink this water, and have whet ever predicament you’re
having no matter how you shake, rattle and roll it. So go with the cosmic
flow and always choose something over nothing, while remembering that
there’s a little of each one hidden in both. 8. Respond as best as you
can with love to adversity rather than reacting with fear... Love, in any
situation and being the primordial source and essence of ALL THIS STUFF,
leaves / enters us with the most possible ways out / in. 9. Whatever you’re doing,
celebrate the process of doing as much, if not more, than what you’ve got
when you’re done. Magic lives in the action. 9 ½ . All matter is energy.
All energy is infinite. We are but raindrops falling to the ocean, a short
time in this shape until we’re reunited with the expanse from which we came.
Your delicate yet sturdy, resilient body is a temporary shelter of energy
that has swam the universe eternally and will continue eternally. You are a
sudden crystallization of the infinite. One must ask themself, therefore,
why be bored? 9 3/4 . Choosing to live in
the moment is courageous but becomes effortless once you begin...feeling
obligated to survive in the past or future is dangerous and is difficult to
continue. It’s one of the few risks I’d recommend not taking, right up there
with trusting icons and shrugging off coincidences. 10. The Universe itself it
not confusing, we humans just like it that way. Do frogs seem bewildered ,
butterflies befuddled and amoebas addled? Nope, just us, my child. So,
whenever things just don’t make sense, just take a deep breath and laugh as
best you can, because that’s what you get for choosing this goofy,
unpredictable place called Earth to embody yourself upon.
0. If you find yourself wonderstruck, don’t forget to return the favor.
1. Always be of service to the whole and the Holy. You’ll find that the Holy will reciprocate by being of service to your becoming Whole.
2. You will be called upon to use your mind and your vision in ways I cannot possibly glimpse. Never turn down an offer to shine that light so uniquely yours to help others in their darkness, and you’ll find that when it’s your turn to be in the night that there’ll be someone along the way who happens to have a little glow to share .
3. The rewards of being true to yourself are infinite, even when outwardly your efforts are met with nothing.
4. You’ll also see that knowledge and wisdom will come from within yourself through your own struggle and curiosity... your loved ones may guide you to insight, but yours is the power to choose it.
5. You’ll find that some of your choices could’ve been better, or at times were downright stupid. That’s okay... I have a closet full of reckless decisions, but without making them I wouldn’t have the slightest idea of what a good one might feel like if I tried it on.
6. Your growth will be a mysterious, comic, ecstatic and sometimes scary ride, and I pray that you strive to savor each minute of it, even the most difficult or embarrassing minutes. Don’t count on second chances.
7. In those times when everything collapses around you, and what’s left won’t go right, don’t forget your chances of being alive in this solar system, in this galaxy, are a little on the slim side. So slim in fact that it could be called a miracle to breathe this air, drink this water, and have whet ever predicament you’re having no matter how you shake, rattle and roll it. So go with the cosmic flow and always choose something over nothing, while remembering that there’s a little of each one hidden in both.
8. Respond as best as you can with love to adversity rather than reacting with fear... Love, in any situation and being the primordial source and essence of ALL THIS STUFF, leaves / enters us with the most possible ways out / in.
9. Whatever you’re doing, celebrate the process of doing as much, if not more, than what you’ve got when you’re done. Magic lives in the action.
9 ½ . All matter is energy. All energy is infinite. We are but raindrops falling to the ocean, a short time in this shape until we’re reunited with the expanse from which we came. Your delicate yet sturdy, resilient body is a temporary shelter of energy that has swam the universe eternally and will continue eternally. You are a sudden crystallization of the infinite. One must ask themself, therefore, why be bored?
9 3/4 . Choosing to live in the moment is courageous but becomes effortless once you begin...feeling obligated to survive in the past or future is dangerous and is difficult to continue. It’s one of the few risks I’d recommend not taking, right up there with trusting icons and shrugging off coincidences.
10. The Universe itself it not confusing, we humans just like it that way. Do frogs seem bewildered , butterflies befuddled and amoebas addled? Nope, just us, my child. So, whenever things just don’t make sense, just take a deep breath and laugh as best you can, because that’s what you get for choosing this goofy, unpredictable place called Earth to embody yourself upon.